Therapy of lupus nephritis with mycophenolate mofetil
نویسندگان
چکیده
منابع مشابه
Treatment of lupus nephritis by mycophenolate mofetil.
BACKGROUND/AIMS Mycophenolate mofetil (MMF) has been increasingly used for the treatment of lupus nephritis (LN). The aim of this study was to examine the efficacy and safety of MMF used with low doses of corticosteroids as maintenance therapy in patients with LN. METHODS The study covered 35 patients, most of them with proliferative types of LN (5 WHO class III, 26 class IV), while 1 had cla...
متن کاملMycophenolate mofetil therapy in lupus nephritis: clinical observations.
Controlled clinical trials in renal transplantation have demonstrated that mycophenolate mofetil is well tolerated and has lower renal transplant rejection rates than azathioprine regimens. This study reports on the clinical experiences at two institutions with mycophenolate mofetil (MMF) for severe lupus nephritis. Twelve patients with relapsing or resistant nephritis previously treated with c...
متن کاملFetal malformations associated with mycophenolate mofetil for lupus nephritis.
Sir, Mycophenolate mofetil (MMF) has become a major therapeutic option as an induction and maintenance therapy for lupus nephritis [1,2]. Many patients with lupus are women of child-bearing age, so the issue of teratogenicity associated with MMF is important. MMF has been classified as category C by the American Food and Drug Administration. In other words, animal reproductive studies have show...
متن کاملRole of mycophenolate mofetil in the treatment of lupus nephritis.
Mycophenolate mofetil (MMF) is an immunosuppressive drug successfully used for the prevention of acute and chronic rejection of renal allografts, as well as in the therapy of glomerular disorders. We treated three groups of patients with lupus nephritis: the first group of patients had a high histologic activity index (AI), 13.4 +/- 2.34; the second group of patients had a high histologic chron...
متن کاملMycophenolate mofetil in the treatment of lupus nephritis
Intravenous cyclophosphamide (IVCP) in combination with oral steroids (ST) is the most widely accepted therapy for severe lupus nephritis (LN); however, its side effects, lack of response and relapses, have led to other treatment alternatives. being sought. Mycophenolate mofetil (MMF) has been shown to be effective in these cases. We studied the course over 12 months of 28 patients with LN WHO ...
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ژورنال
عنوان ژورنال: Medicinski pregled
سال: 2008
ISSN: 0025-8105,1820-7383
DOI: 10.2298/mpns0806270c